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Then maybe the recipient's mail server is not Domino?
Sorry, but it's not clear to me who you're sending the message to -- a Domino recipient or a non-Domino recipeint. I'm pretty certain it is leaving the Domino server, going to a postfix server somewhere, and being rejected because the postfix server doesn't like something about the sender address... but I could be wrong about that, of course.
Also, I'm not sure if it's the From header in the message or the MAIL FROM in the SMTP transaction that postfix would be having a problem with.
-rich
Feedback response number WEBB9DF74V created by ~Ned Nimfanakonyoopsi on 11/14/2013